Beta Secretase Activity
ß-Secretase (BACE) is a membrane-bound aspartyl protease that cleaves the amyloid precursor protein to generate the N-terminus of the amyloid beta peptide. ß-Secretase has been implicated to be an excellent target for anti-amyloid therapy for the treatment of Alzheimers disease. Finding inhibitors of ß-secretase is one of the major goals of Alzheimers disease drug development. BioCats ß-Secretase Fluorometric Assay Kit provides a convenient, nonradioactive system for detecting ß-Secretase activity in biological and purified samples. The kit provides active ß-Secretase as the positive control, ß-Secretase inhibitor as the negative control, as well as the optimized substrate and buffers for convenient measurement of ß-Secretase activity in mammalian samples.