Web Version

Webinar Invitation

Paving the Way for 3D Genome Engineering and Therapy in Hemoglobinopathies

Friday, 24th September 2021

1:00 PM Central European Time | REGISTER

All registrants will receive a link to the recorded version.

Dr. Xiaotian Zhang will be joining us live to talk about his recent work on hemoglobinopathies, applying Arima's HiC and Capture-HiC to examine the changes to 3D chromatin organization at the β-globin locus.

A 3D View of the Genome
Using CRISPR-Cas9, Dr. Zhang's team found that 3'HS1 deletion induces the γ-globin gene activation and alteration of chromosomal loops in the β-globin locus. Specifically, 3'HS1 deletion incorporates an insulated enhancer to activate the γ-globin gene.

A Target for Gene Therapy
Altering the CTCF binding profile across the locus can significantly change the expression of the -globin genes, suggesting that genetic editing of this binding site can have therapeutic implications to treat hemoglobinopathies.

Dr. Xiaotian Zhang
Research Investigator
University of Michigan

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